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The Research & Science of Carbon 60

Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro

Hong Ji , Zhanqiu Yang , Wenling Jiang , Chun Geng , Ming Gong , Hong Xiao , Zhijie Wang & Li Cheng
Journal of Huazhong University of Science and Technology [Medical Sciences] volume 28, pages243–246(2008)

The activity of nanocarbon fullerene lipidosome (NCFL) against influenza virus H1N1 in vitro was studied. There was a dose-activity relationship between the dosages of NCFL and the direct killing effect against the influenza virus, and the periods of lighting-time could influence the activity partly. It was concluded that NCFL had a significant activity of directly killing the influenza virus.

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Anti-Influenza Activity of C60 Fullerene Derivatives

Masaki Shoji,Etsuhisa Takahashi,Dai Hatakeyama,Yuma Iwai,Yuka Morita,Riku Shirayama,Noriko Echigo,Hiroshi Kido,Shigeo Nakamura,Tadahiko Mashino,Takeshi Okutani,Takashi Kuzuhara

In a cell culture system, we found that several fullerene derivatives inhibit influenza A viral infection and the expression of influenza A nucleoprotein and nonstructural protein 1. These results indicate that fullerene derivatives are possible candidates for the development of novel anti-influenza drugs.

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Anti-Influenza Activity of C60

Inhibit Viruses

Medicinal applications of fullerenes

Rania Bakry, Rainer M Vallant, Muhammad Najam-ul-Haq, Matthias Rainer, Zoltan Szabo, Christian W Huck, and Günther K Bonn

Fullerenes (C60) and their derivatives have potential antiviral activity, which has strong implications on the treatment of HIV-infection. The antiviral activity of fullerene derivatives is based on several biological properties including their unique molecular architecture and antioxidant activity.

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Knock Out Viruses

Fullerene compounds knock out virus infections like HIV and HSV

Skolkovo Institute of Science and Technology

Scientists from the Skoltech Center for Energy Science and Technology and the Institute of Problems of Chemical Physics of RAS in collaboration with researchers from four other Russian and foreign research centers have discovered a new reaction that helps obtain water-soluble fullerene derivatives which effectively combat flu viruses, human immunodeficiency virus (HIV), herpes simplex virus (HSV), and cytomegalovirus (CMV).

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Inhibit Viruses

Fullerenes in biology

Anita Krokosz

Results of previous studies point to the great dependance of fullerenes activity upon quality, quantity and geometry of substituents in fullerene derivatives. Some of fullerene derivatives show antiviral and antimicrobial activity, including anti-HIV properties. C60 and its derivatives are able to exhibit cytotoxic and enzyme-inhibiting abilities as well as radical-quenching and antioxidative abilities. Generation of reactive oxygen species under influence of visible light is another ability of fullerene derivetives desired in photodynamic therapy.

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Inhibit Influenza A

Inhibition of Group A Streptococcus Infection by Carboxyfullerene

Nina Tsao, Tien-Yau Luh, Chen-Kung Chou, Jiunn-Jong Wu, Yee-Shin Lin, Huan-Yao Lei

 Furthermore, carboxyfullerene was able to directly inhibit in vitro growth of S. pyogenes. These data suggest that carboxyfullerene can be considered an antimicrobial agent for group A streptococcus infection.

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Effective against wrinkles

Fullerene is effective against wrinkles

To experimentally prove the effectiveness of fullerene/squalane, an 8-week double-blind clinical test was conducted on 23 female volunteers aged between 30 and 40 years according to the Japanese guidelines for the evaluation of antiwrinkle creams…Thus, fullerene/squalane can be used for antiwrinkle treatment, and fullerene may be useful for care after antiwrinkle LASER treatment.



Fullerenes as Anti-Aging Antioxidants

Yuliana P Galvan, Igor Alperovich 1, Petr Zolotukhin, Evgenia Prazdnova, Maria Mazanko, Anna Belanova, Vladimir Chistyakov

Here we review fullerenes biological effects focusing on their antioxidant and anti-ageing action. A scope of various poisonous and healing properties reported in literature for fullerene and its derivatives is analyzed.

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Prevent UV Damage

Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue

Shinya Kato 1, Hisae Aoshima, Yasukazu Saitoh, Nobuhiko Miwa

C60 was not detected in the dermis by HPLC, suggesting no necessity for considering a toxicity of C60 due to systemic circulation via dermal veins. Thus Lpsm-Flln has a potential to be safely utilized as a cosmetic anti-oxidative ingredient for UVA-protection


Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis

Kazuo Yudoh 1, Kiyoshi Shishido, Hideki Murayama, Mitsunobu Yano, Kenji Matsubayashi, Hiroya Takada, Hiroshi Nakamura, Kayo Masuko, Tomohiro Kato, Kusuki Nishioka

In rabbits with OA, treatment with water-soluble C60 significantly reduced articular cartilage degeneration, whereas control knee joints showed progression of cartilage degeneration with time. This inhibitory effect was dose-dependent, and was superior to that of HA. Combined treatment with C60 and HA yielded a significant reduction in cartilage degeneration compared with either treatment alone.

Conclusion: The results indicate that C60 fullerene is a potential therapeutic agent for the protection of articular cartilage against the progression of OA.


Fullerol nanoparticles suppress inflammatory response

Qihai Liu, PhD, Li Jin, MD, PhD, Francis H. Shen, MD, Gary Balian, PhD, and Xudong Joshua Li, MD, PhD*

Thus, fullerene has been characterized as a “free radical sponge”, with an anti-oxidative efficacy of several hundred-fold higher than conventional antioxidants [19]. Fullerene and its derivatives were found to be in many biological applications: inhibition of nitric oxide formation by suppressing nitric oxide synthase [20], prevention of ischemia-induced injuries in brain [21], inactivation of viruses [22] and prevention of quartz-induced neutrophilic inflammation in the lungs [23]. Furthermore, a Japanese group showed that a water-soluble fullerene prevented the development of cartilage degeneration and arthritis with no detectable toxicity when intraarticularly injected into rabbits of an osteoarthritis model [24].