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Greska's
Carbon-60

Research

The Research & Science of Carbon 60

Carbon 60 inhibits Allergic Response

Title: Fullerene Nanomaterials Inhibit the Allergic Response
Author: John J. RyanHenry R. BatemanAlex StoverGreg GomezSarah K. NortonWei Zhao.

Abstract: Fullerenes prevented the in vivo release of histamine and drop in core body temperature in vivo using a Mast Cell-dependent model of anaphylaxis. These findings identify a new biological function for fullerenes and may represent a novel way to control Mast Cell-dependent diseases including asthma, inflammatory arthritis, heart disease, and multiple sclerosis.

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Carbon 60 Woman's Health

Title: Vagina Biome Study
Author: Alyssa Blue, FDNP
Abstract: Utilizing Greska’s Carbon-60 for managing vaginal microbiome imbalances appears to be promising. Carbon 60 showed beneficial shifts in the vagina’s protective Lactobacillus bacteria.

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Anti-Aging

Title: Fullerenes as Anti-Aging Antioxidants​ Author: Yuliana P Galvan, Igor Alperovich 1, Petr Zolotukhin, Evgenia Prazdnova, Maria Mazanko, Anna Belanova, Vladimir Chistyakov
Abstract: Here we review fullerenes biological effects focusing on their antioxidant and anti-ageing action. A scope of various poisonous and healing properties reported in literature for fullerene and its derivatives is analyzed. The review begins with the history of fullerenes discovery and their main properties. Then we focus on the longevity and antioxidant action, including the confrontation of available experimental data and theoretical modeling of buckminsterfullerene C60.
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Carbon 60 enhances immune function

Title: The polyhydroxylated fullerene derivative C60(OH)24protects mice from ionizing-radiation-inducedimmune and mitochondrial dysfunction
Author: Xiaoqing Cai 1, Jiejie Hao, Xiaoyong Zhang, Bozhang Yu, Jinming Ren, Cheng Luo, Qingnuan Li, Qing Huang, Xianglin Shi, Wenxin Li, Jiankang Liu
Abstract: These results suggest that the polyhydroxylated fullerene derivative C(60)(OH)(24) protects against ionizing-radiation-induced mortality, possibly by enhancing immune function, decreasing oxidative damage and improving mitochondrial function.

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Carbon 60 Research

Keywords: Radical Scavenging, Anticancer, Anti-Bacterial, Anti-Fungal, Anti-Viral, Safety, Mitochondria, Inflammation, UV Protection/Wrinkles, Hair Growth, Wound Healing

Title: Fullerene C60 with cytoprotective and cytotoxic potential: prospects as a novel treatment agent in Dermatology?
Author: Angelique Rondags,Wing Yan Yuen,Marcel F. Jonkman,Barbara Horváth
Abstract: Novel treatment agents with the ability to scavenge or generate radicals can potentially be meaningful in the treatment of various skin diseases, especially for those diseases that have limited effective treatment options. This viewpoint essay will discuss the potential of fullerene C60, i.e. buckminsterfullerene, derivatives as novel treatment agents in dermatology.

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Anti-Influenza Activity of Carbon 60

Title:Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro
Author: Hong Ji , Zhanqiu Yang , Wenling Jiang , Chun Geng , Ming Gong , Hong Xiao , Zhijie Wang & Li Cheng <br>Journal of Huazhong University of Science and Technology [Medical Sciences] volume 28, pages243–246(2008)
Abstract: The activity of nanocarbon fullerene lipidosome (NCFL) against influenza virus H1N1 in vitro was studied. There was a dose-activity relationship between the dosages of NCFL and the direct killing effect against the influenza virus, and the periods of lighting-time could influence the activity partly. It was concluded that NCFL had a significant activity of directly killing the influenza virus.

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Title: Anti-Influenza Activity of C60 Fullerene Derivatives​
Author: Masaki Shoji,Etsuhisa Takahashi,Dai Hatakeyama,Yuma Iwai,Yuka Morita,Riku Shirayama,Noriko Echigo,Hiroshi Kido,Shigeo Nakamura,Tadahiko Mashino,Takeshi Okutani,Takashi Kuzuhara
Abstract: In a cell culture system, we found that several fullerene derivatives inhibit influenza A viral infection and the expression of influenza A nucleoprotein and nonstructural protein 1. These results indicate that fullerene derivatives are possible candidates for the development of novel anti-influenza drugs.

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Anti-Influenza Activity of C60 Inhibit Viruses

Title:Medicinal applications of fullerenes
Author: Rania Bakry, Rainer M Vallant, Muhammad Najam-ul-Haq, Matthias Rainer, Zoltan Szabo, Christian W Huck, and Günther K Bonn
Abstract: Fullerenes (C60) and their derivatives have potential antiviral activity, which has strong implications on the treatment of HIV-infection. The antiviral activity of fullerene derivatives is based on several biological properties including their unique molecular architecture and antioxidant activity.

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Carbon 60 Knocks Out Viruses

Title: Fullerene compounds knock out virus infections like HIV and HSV
Author: Skolkovo Institute of Science and Technology
Abstract: Scientists from the Skoltech Center for Energy Science and Technology and the Institute of Problems of Chemical Physics of RAS in collaboration with researchers from four other Russian and foreign research centers have discovered a new reaction that helps obtain water-soluble fullerene derivatives which effectively combat flu viruses, human immunodeficiency virus (HIV), herpes simplex virus (HSV), and cytomegalovirus (CMV).

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C60 Inhibits Viruses

Title: Fullerenes in biology
Author: Anita Krokosz
Abstract: Results of previous studies point to the great dependance of fullerenes activity upon quality, quantity and geometry of substituents in fullerene derivatives. Some of fullerene derivatives show antiviral and antimicrobial activity, including anti-HIV properties. C60 and its derivatives are able to exhibit cytotoxic and enzyme-inhibiting abilities as well as radical-quenching and antioxidative abilities. Generation of reactive oxygen species under influence of visible light is another ability of fullerene derivetives desired in photodynamic therapy.

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Carbon 60 Inhibits Influenza A

Title: Inhibition of Group A Streptococcus Infection by Carboxyfullerene
Author: Nina Tsao, Tien-Yau Luh, Chen-Kung Chou, Jiunn-Jong Wu, Yee-Shin Lin, Huan-Yao Lei
Abstract: Furthermore, carboxyfullerene was able to directly inhibit in vitro growth of S. pyogenes. These data suggest that carboxyfullerene can be considered an antimicrobial agent for group A streptococcus infection.

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C60 Effective against wrinkles

Title: Fullerene is effective against wrinkles
Author: Journal of the American Academy of Dermatology
Abstract: To experimentally prove the effectiveness of fullerene/squalane, an 8-week double-blind clinical test was conducted on 23 female volunteers aged between 30 and 40 years according to the Japanese guidelines for the evaluation of antiwrinkle creams…Thus, fullerene/squalane can be used for antiwrinkle treatment, and fullerene may be useful for care after antiwrinkle LASER treatment.

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Anti-Aging Effects of C60

Title: Fullerenes as Anti-Aging Antioxidants
Author: Yuliana P Galvan, Igor Alperovich 1, Petr Zolotukhin, Evgenia Prazdnova, Maria Mazanko, Anna Belanova, Vladimir Chistyakov
Abstract: Here we review fullerenes biological effects focusing on their antioxidant and anti-ageing action. A scope of various poisonous and healing properties reported in literature for fullerene and its derivatives is analyzed.

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Carbon 60 Can Prevent UV Damage

Title: Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue
Author: Shinya Kato 1, Hisae Aoshima, Yasukazu Saitoh, Nobuhiko Miwa
Abstract: C60 was not detected in the dermis by HPLC, suggesting no necessity for considering a toxicity of C60 due to systemic circulation via dermal veins. Thus Lpsm-Flln has a potential to be safely utilized as a cosmetic anti-oxidative ingredient for UVA-protection

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C60 prevents Degeneration of Articular Cartilage in Osteoarthritis

Title:Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis
Author: Kazuo Yudoh 1, Kiyoshi Shishido, Hideki Murayama, Mitsunobu Yano, Kenji Matsubayashi, Hiroya Takada, Hiroshi Nakamura, Kayo Masuko, Tomohiro Kato, Kusuki Nishioka​
Abstract: In rabbits with OA, treatment with water-soluble C60 significantly reduced articular cartilage degeneration, whereas control knee joints showed progression of cartilage degeneration with time. This inhibitory effect was dose-dependent, and was superior to that of HA. Combined treatment with C60 and HA yielded a significant reduction in cartilage degeneration compared with either treatment alone.

Conclusion: The results indicate that C60 fullerene is a potential therapeutic agent for the protection of articular cartilage against the progression of OA.

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Carbon 60 Suppress Inflammatory Response

Title: Fullerol nanoparticles suppress inflammatory response
Author: Qihai Liu, PhD, Li Jin, MD, PhD, Francis H. Shen, MD, Gary Balian, PhD, and Xudong Joshua Li, MD, PhD*
Abstract: Thus, fullerene has been characterized as a “free radical sponge”, with an anti-oxidative efficacy of several hundred-fold higher than conventional antioxidants [19]. Fullerene and its derivatives were found to be in many biological applications: inhibition of nitric oxide formation by suppressing nitric oxide synthase [20], prevention of ischemia-induced injuries in brain [21], inactivation of viruses [22] and prevention of quartz-induced neutrophilic inflammation in the lungs [23]. Furthermore, a Japanese group showed that a water-soluble fullerene prevented the development of cartilage degeneration and arthritis with no detectable toxicity when intraarticularly injected into rabbits of an osteoarthritis model [24].

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